Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
BMB-22-119BİOREACTORSElective116
Level of Course Unit
Second Cycle
Objectives of the Course
To learn about reactor types used for growing living systems. Students will gain knowledge of bioreactor design principles and issues related to the operation of reactors, especially under scale-up conditions.
Name of Lecturer(s)
Dr. Öğr. Üye Mehmet Selim ŞILBIR
Learning Outcomes
1Gaining the ability to express the general properties of bioreactors
2Ability to describe strategies associated with scaling up
3Ability to use information search methods and modern library searches to learn about topics related to biorectors
4Ability to read scientific literature and interpret information about biomolecular structure and function.
5Following the innovations in science, gaining the skill of self-development and being an effective team worker
6Ability to express results with oral presentations
Mode of Delivery
Daytime Class
Prerequisites and co-requisities
none
Recommended Optional Programme Components
none
Course Contents
Stirred tank reactor, packed bed reactor, air lift reactor, fluidized bed reactor, bubble girth reactor. Management analysis of bioreactor process, oxygen mass transfer in bioreactors – microbial oxygen demand; methods used to determine the mass transfer coefficient; mass transfer relations. Scale-down and scale-up criteria for bioreactors based on oxygen transfer, energy consumption and propeller speed
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Introduction to bioreactors and various reactor types
2Features and configuration of the stirred tank reactor
3Packed bed reactor – configuration, advantages, disadvantages and applications
4Air lift reactor and bubble column reactor - configuration, advantages, disadvantages and applications
5Fluidized bed reactor - configuration, advantages, disadvantages and applications
6Management analysis of the bioreactor process
7Problem solving
8Mid-term Exam
9Oxygen mass transfer in bioreactors, gas-liquid mass transfer
10Oxygen mass transfer in bioreactors
11Methods used to determine the mass transfer coefficient
12Instrumentation and control
13Scale-up and down-scale criteria for bioreactors
14Problem solving
15Final Project Presentation
16Final Exam
Recommended or Required Reading
Binoy Ranjan Maiti, Principles of Bioreactor Design (2018) Michael Shuler, Fikret Kargi, Matthew DeLisa, Bioprocess Engineering: Basic Concepts (Prentice Hall International Series in the Physical and Chemical Engineering Sciences) 3rd Edition (2017) Carl‐Fredrik Mandenius, Design, Operation and Novel Applications (2016) C. Radledge, B. Kristiansen, “Basic Biotechnology”, Second Edition,, Cambridge University Press, (2001)
Planned Learning Activities and Teaching Methods
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Examination1100
SUM100
Term (or Year) Learning Activities50
End Of Term (or Year) Learning Activities50
SUM100
Language of Instruction
English
Work Placement(s)
none
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Tutorial14228
Project Preparation22550
Project Presentation22040
Self Study4520
Individual Study for Mid term Examination155
Individual Study for Final Examination11010
Reading248
TOTAL WORKLOAD (hours)193
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
PO
13
LO154 3 3       
LO255 444       
LO34345435 4 5 5
LO45335335 4 4 5
LO533  3534544 5
LO63    44 455  
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Iğdır University, Iğdır / TURKEY • Tel (pbx): +90 476 226 13 14 • e-mail: info@igdir.edu.tr